Research: Obesity Associated with Elevated Risk of Dementia

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A meta-analysis published in November of 2017 looked at this very subject by pooling the data from 1.3 million adults from 39 prospective cohort studies[1].  The researchers examined this hypothesis in over 1.3 million dementia-free participants from 39 cohort studies.  BMI was assessed at baseline.  Dementia in 6894 patients was ascertained at follow-up using electronic health records.  The researchers calculated a hazard ratio at 10 years, 10-20 years, and >20 years before dementia diagnosis which basically determines the hazard of developing dementia.  The researchers felt there was a link between BMI and dementia.  The connection was perceived to be likely one of two different processes: a harmful effect of higher BMI, which is observable in extended follow-up, and a reverse-causation effect that makes a higher BMI appears to be protective when the follow-up is short.  I would suggest that the cause could also be from the insulin resistance caused by excess central obesity but to be honest, this study cannot determine causation.  

The bottom line: Use this study as motivation to lose weight.  It is not earth-shattering.  In this study, a higher BMI was associated with increased risk of dementia.  Most research is needed because there is a significant limitation in this study.  

Footnotes
[1]Kivimäki et al., “Body Mass Index and Risk of Dementia: Analysis of Individual-Level Data from 1.3 Million Individuals.”
Kivimäki, Mika, Ritva Luukkonen, G. David Batty, Jane E. Ferrie, Jaana Pentti, Solja T. Nyberg, Martin J. Shipley, et al. “Body Mass Index and Risk of Dementia: Analysis of Individual-Level Data from 1.3 Million Individuals.” Alzheimer’s & Dementia, November 2017. https://doi.org/10.1016/j.jalz.2017.09.016.
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About the Author

ChuckH
I am a family physician who has served in the US Army. In 2016, I found myself overweight, out of shape, and unhealthy, so I made a change to improve my health. This blog is the chronology of my path to better health and what I have learned along the way.

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